Watch Six Nations Live Twelvetrees will line up at inside centre in one of two changes to the side that beat New Zealand last time out with Joe Marler also stepping in for the injured Alex Corbisiero at loose-head. Brad Barritt will revert to the outside centre role while hooker Tom Youngs has held off the challenge of a fit-again Dylan Hartley. Ben Youngs edges out Danny Care for the No.9 jersey and Alex Goode returned from a shoulder injury in time to retain the full-back berth.
Scotland - Player to Watch: The rapid promotion of New Zealand-born winger Sean Maitland has raised a few eyebrows but he qualifies through his grandfather and will no doubt be desperate to win over any doubters with an eye-catching display.
Scotland - Team News: Maitland is set to win his first cap as one of six changes to the side upset by Tonga. No.8 Johnnie Beattie earns a recall for the first time since 2011 while hooker Dougie Hall returns to the starting line-up after a six year break. Ruaridh Jackson is named at fly-half with Greig Laidlaw switching to the No.9 shirt for the first time and Sean Lamont moves from wing to centre. In the pack, Ryan Grant returns from injury at loose-head prop and Jim Hamilton is recalled to partner Richie Gray in the second row. Kelly Brown will lead the side from openside flanker.
Key Battle: A bruising battle awaits at Twickenham - especially up front - and expect captains and rival opensides Chris Robshaw and Kelly Brown to be in the thick of the action. Both players have been among the top performers in the Premiership this season but that will count for little come kick off. Which player will be able to get his side onto the front foot - and keep them there?
Trivia: England have won six out of the nine matches that referee Alain Rolland has officiated in the Six Nations. Scotland have only won one out of the six matches that Rolland has officiated in, most recently refereeing them in their 13-6 loss to Italy last year.
Stats: Scotland have only scored one try against England in the last five meetings between the two sides with that score coming from Max Evans in 2011.
Betting: There has been very little between these two sides of late so you may be tempted by Bet365's offer of 11/2 for an England win between 6-10 points. Or do you fancy Scotland debutant Scott Maitland to grab a try on his debut? Bet365 have the New Zealand-born winger at 14/1 to grab the first try or 7/2 to cross the whitewash at any point in the game.